２−［（３，５−ジフルオロ−３’−メトキシ−１，１’−ビフェニル−４−イル）アミノ］ニコチン酸の製造方法

摘要

This invention is directed to a process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid, which comprises the steps of:
a) providing 3,5-difluoro-3'-methoxybiphenyl-4-amine,
b) preparing and isolating an aminium salt of the 3,5-difluoro-3'-methoxybiphenyl-4-amine, and
c) further reacting the aminium salt of 3,5-difluoro-3'-methoxybiphenyl-4-amine obtained in b) to obtain 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid.