SYSTEM AND METHOD FOR A BIOMIMETIC FLUID PROCESSING
摘要
A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
申请公布号
EP2941642(A1)
申请公布日期
2015.11.11
申请号
EP20130870350
申请日期
2013.11.20
申请人
BRIGHAM AND WOMEN'S HOSPITAL, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;VILNIUS UNIVERSITY
发明人
ITALIANO, JOSEPH;MAZUTIS, LINAS;THON, JONATHAN, N.;WEITZ, DAVID, A.