发明名称 |
A NEW METHOD FOR PRODUCING ANTIFOLATE AGENTS HAVING GLUTAMIC ACID PART IN THEIR STRUCTURE |
摘要 |
<p>A method for producing antifolate agents having glutamic acid part in their structure is developed by protecting carboxyl groups of glutamic acid or its N-substituted derivatives as cyanomethyl ester to give compounds of formula (II) which are hydrolyzed under very mild conditions to afford antifolate agents in high yield with high analytical and optical purity.</p> |
申请公布号 |
EP2646442(B1) |
申请公布日期 |
2015.11.11 |
申请号 |
EP20100807503 |
申请日期 |
2010.12.03 |
申请人 |
KOCAK FARMA ILAC VE KIMYA SAN. A.S |
发明人 |
KOCAK, ENDER;ASLAN, TUNCER |
分类号 |
C07D475/08 |
主分类号 |
C07D475/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|