Complement inhibitors for treatment of injury from intracerebral hemorrhage

摘要

Methods for treating or ameliorating the damage resulting from intracerebral hemorrhage are disclosed. The methods involve administration of a complement inhibitor to inhibit C3a or C5a formation or activity in the affected tissue. Pharmaceutical compositions suitable for use in the methods of the invention are also provided.

主权项

1. A method for treating or reducing injury resulting from intracerebral hemorrhage in an individual, the method comprising administering a therapeutically effective amount of at least one complement inhibitor to the individual, wherein the at least one complement inhibitor reduces or prevents C3a and C5a formation or activity, thereby treating or preventing the injury resulting from intracerebral hemorrhage, and wherein the at least one complement inhibitor comprises:
(a) a C3 inhibitor, a C4 inhibitor, or a combination thereof; or (b) a C3 inhibitor, a C3aR inhibitor, or a C4 inhibitor in combination with:
(i) a C5a inhibitor;(ii) a C5aR inhibitor; or(iii) a C5a inhibitor and a C5aR inhibitor.