METHOD FOR DISCOVERING ANTICONVULSANT ACTION OF CITICOLINE IN PENTYLENETETRAZOLE KINDLING MODEL INVOLVING MALE C57B1/6 MICE

摘要

FIELD: medicine.SUBSTANCE: discovering process is shown in pentylenetetrazole kindling model involving male C57B1/6 mice. Action of citicoline is determined after administered in a dose of 500 mg/kg one hour before administration of pentylenetetrazole. The administration is conducted in the different regimens in different groups of animals, in particular: daily during 24 days, once on the 14day of kindling or during 14 days of kindling.EFFECT: possibility to discover a spectrum and degree of manifestation of anticonvulsant action of the preparation.2 tbl