| 发明名称 |
Method of using attenuated bordetella strains |
| 摘要 |
A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided. |
| 申请公布号 |
US9180178(B2) |
申请公布日期 |
2015.11.10 |
| 申请号 |
US201514658817 |
申请日期 |
2015.03.16 |
| 申请人 |
Institut Pasteur de Lille;Institut National de la Sante et de la Recherche Medicale (INSERM) |
发明人 |
Locht Camille;Mielcarek Nathalie;Debrie Anne-Sophie;Raze Dominique;Bertout Julie |
| 分类号 |
A01N63/00;A61K39/02;A61K39/00 |
主分类号 |
A01N63/00 |
| 代理机构 |
|
代理人 |
Kim Stanley A. |
| 主权项 |
1. A method for protecting a subject against disease caused by Bordetella infection, comprising administering to the subject in need of such treatment a live attenuated Bordetella pertussis strain comprising at least a mutated pertussis toxin (ptx) gene, a deleted or mutated dermonecrotic (dnt) gene, and a heterologous ampG gene replacing the Bordetella ampG gene, wherein the strain is able to colonize and induce protective immunity in the subject. |
| 地址 |
FR |
