Sophorae Radix extract for prevention and treatment of respiratory diseases

摘要

The present invention relates to an extract isolated from Sophorae Radix useful for prevention and treatment of respiratory diseases. More specifically, the present invention relates to a pharmaceutical drug comprising the Sophorae Radix extract having excellent effects of inhibiting airway contraction, respiratory infections, 5-lipoxygenase activity, phosphodiesterase 4 activity, airway hyper-responsiveness and airway remodeling; antagonistic activity against leukotriene D4; and an antitussive effect, thus being useful for prevention and treatment of respiratory diseases such as asthma, acute or chronic bronchitis, allergic rhinitis, acute upper respiratory infections and acute lower respiratory infections, and the like.

主权项

1. A method of treating asthma, cough, or allergic rhinitis in a patient in need thereof comprising administering to the patient an effective amount of a purified extract of Sophorae subprostratae Radix, wherein the extract is prepared by the steps of:
(a) extracting Sophorae subprostratae Radix with an ethanol solution, (b) filtering the ethanol extract solution, collecting the filtrate, and concentrating the filtrate; (c) adding a water-saturated n-butanol solvent to the concentrated filtrate to obtain a water-saturated n-butanol solution, (d) subjecting the water-saturated n-butanol solution to phase separation to obtain an n-butanol fraction, (e) concentrating and drying the n-butanol fraction to produce the purified extract.