High porosity materials, scaffolds, and method of making

摘要

Materials and methods for preparing three dimensional scaffolds are described. The materials, as improved high internal phase emulsions (HIPES), and the polymerization thereof may be suitable for injection prior to curing and when in an injectable form may be for site-directed in vivo use, curing after injection. In addition, said materials before curing may be engineered as a tissue substitution or enhancement and/or to include cell encapsulation. Said materials described herein form a monolith after curing and are biodegradable and porous after curing. Said materials are made from starting molecules using a process that does not rely on toxic solvents or monomers. Making of said materials to form the emulsion take advantage of one or more surfactants for HIPE stability. In addition, said materials cure at temperatures appropriate for use in an in vivo or in situ environment.

主权项

1. A high internal phase emulsion composition comprising:
a biodegradable macromer obtained from a two-step reaction comprising backbone formation and functionalization forming reactive end groups for crosslinking the biodegradable macromer at a temperature below 40 degrees Centigrade, the biodegradable macromer provided as a blend without a toxic diluent and with a surfactant lacking polar head group hydrogen bond donor sites; an electrolyte to prevent Ostwald ripening; a free radical initiator for crosslinking; and water, the high internal phase emulsion polymerizable at the temperature below 40 degrees Centigrade.