Morpholine compounds and uses thereof

摘要

The present invention relates to compounds of formula;
wherein R1 and R2 are as described herein. Compounds of the invention are useful in the treatment and/or prophylaxis of diseases associated with TAAR modulation.

主权项

1. A compound of formula whereinR1 is a one or two membered heteroaryl group, selected from the group consisting ofR2 is hydrogen or halogen; orR1 and R2 may form together with the carbon atoms to with they are attached the following ringsR3 is hydrogen, halogen or lower alkyl;
n is 1 or 2;R4 is phenyl, optionally substituted by one or two substituents, selected from halogen or cyano, or is
pyridinyl, optionally substituted by halogen, or is tetrahydropyran, or is —NH—C(O)-phenyl, optionally substituted by halogen;R5 is hydrogen or halogen;R6-R13 are phenyl, optionally substituted by halogen:R14 is —NH—C(O)-phenyl, substituted by halogen;R15 is hydrogen, lower alkyl substituted by halogen or is halogen;R16 is hydrogen or lower alkoxy;R17 is pyridinyl, optionally substituted by lower alkoxy or lower alkyl substituted by halogen;or a pharmaceutically suitable acid addition salt thereof, all racemic mixtures, all their corresponding enantiomers and/or optical isomers and all tautomeric forms of compounds of formula I.