Manufacturing process for pyrimidine derivatives

摘要

The invention relates to new crystalline forms of processes for manufacturing a compound of formula 5,;
or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of said solid forms for the therapeutic treatment of warm-blooded animals.

主权项

1. A crystalline form of the compound of formula A or of a hydrate or solvate of the compound of formula A, or of a salt of the compound of formula A, or of a hydrate or solvate of a salt of the compound of formula A, wherein said crystalline form is selected from the group consisting of a crystalline form of the compound of formula A in polymorph Form A anhydrous, a monohydrate of the monohydrochloride salt of the Compound of formula A in polymorph Form Ha, a monohydrochloride salt of the Compound of formula A in polymorph Form A, a monohydrochloride salt of the Compound of formula A in polymorph Form B, a solvate of the monohydrochloride salt of the Compound of formula A in polymorph Form SA, a solvate of the monohydrochloride salt of the Compound of formula A in polymorph Form SB, a solvate of the monohydrochloride salt of the Compound of formula A in polymorph Form SC, a solvate of the monohydrochloride salt of the Compound of formula A in polymorph Form SD, and a solvate of the monohydrochloride salt of the Compound of formula A in polymorph Form SE.