| 主权项 |
1. A compound of formula (A-I), (A-II), (B-I), (B-II), (B-III) and (B-IV):or a tautomer, stereoisomer, enantiomer, diastereomer, salt, or N-oxide thereof, wherein
Ar is selected from substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or Cy1; X1 is CR1 or N; X2 is CR2 or N; X3 is CR3 or N; and X4 is CR4 or N; X is CR or N; Z is CO, O or S(O)q; Cy1 is selected from substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocyclic group; each occurrence of R, R2, and R3 may be same or different and is independently selected from hydrogen, nitro, hydroxy, cyano, halogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 cycloalkyl, substituted or unsubstituted C3-6 cycloalkylalkyl, substituted or unsubstituted C3-6 cycloalkenyl, —ORa, —S(═O)q—Ra, —NRaRb, —C(═Y)—Ra, —CRaRb—C(═Y)—Ra, —CRaRb—Y—CRaRb-, —C(═Y)—NRaRb-, —NRa—C(═Y)—NRaRb-, —S(═O)q—NRaRb-, —NRa—S(═O)q—NRaRb-, and —NRa—NRaRb-; each occurrence of R1 and R4 may be same or different and is independently selected from hydrogen, nitro, hydroxy, halogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 cycloalkyl, substituted or unsubstituted C3-6 cycloalkylalkyl, substituted or unsubstituted C3-6 cycloalkenyl, —ORa, —S(═O)q—Ra, —NRaRb, —C(═Y)—Ra, —CRaRb—C(═Y)—Ra, —CRaRb—Y—CRaRb-, —C(═Y)—NRaRb-, —NRa—C(═Y)—NRaRb-, —S(═O)q—NRaRb-, —NRa—S(═O)q—NRaRb-, and —NRa—NRaRb; each occurrence of Ra and Rb may be same or different and are independently selected from hydrogen, nitro, hydroxy, cyano, halogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 cycloalkyl, substituted or unsubstituted C3-6 cycloalkylalkyl, and substituted or unsubstituted C3-6 cycloalkenyl, or when two Ra and/or Rb substituents are directly bound to a common atom, they may be joined to form (i) an oxo (═O), thio (═S) or imino (═NRd), or (ii) a substituted or unsubstituted, saturated or unsaturated 3-10 member ring, which may optionally include one or more heteroatoms which may be same or different and are selected from O, NRc or S; each occurrence of Rc is independently selected from hydrogen, nitro, hydroxy, cyano, halogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 cycloalkyl, substituted or unsubstituted C3-6 cycloalkylalkyl, and substituted or unsubstituted C3-6 cycloalkenyl; each occurrence of Y is independently selected from O, S, and NRa; and each occurrence of q independently represents 0, 1 or 2; D and E are independently selected from CH or N; R5 is selected from hydrogen, hydroxy, halogen, carboxyl, cyano, nitro, oxo (═O), thio (═S), substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenylalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, —COORa, —C(O)Ra, —C(S)Ra, —C(O)NRaRb, —C(O)ONRaRb, —NRaRb, —NRaCONRaRb, —N(Ra)SORb, —N(Ra)SO2Rb, -(═N—N(Ra)Rb), —NRaC(O)ORb, —NRaC(O)Rb-, —NRaC(S)Rb —NRaC(S)NRaRb, —SONRaRb-, —ORa, —ORaC(O)NRaRb, —ORaC(O)ORb-, —OC(O)Ra, —OC(O)NRaRb, —RaNRbC(O)Ra, —RaORb, —RaC(O)ORb, —RaC(O)NRaRb, —RaC(O)Rb, —RaOC(O)Rb, —SRa, —SORa, —SO2Ra, and —ONO2; with the proviso that when R5 is —SO2Ra, then Ra is not unsubstituted alkyl; each occurrence of Rd is independently hydrogen, hydroxy, halogen, carboxyl, cyano, nitro, oxo (═O), thio (═S), substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenylalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocycicyalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, and —ONO2, or any two of Rd which are directly bound to a common atom may be joined to form (i) a substituted or unsubstituted, saturated or unsaturated 3-14 membered ring, which may optionally include one or more heteroatoms which may be the same or different and are selected from O, NR′ (where R′ is H or alkyl) or S, or (ii) an oxo (═O), thio (═S) or imino (═NR′); and each occurrence of Re, Rf, Rg, Rh, Rj, Rk and Rl is independently selected from hydrogen, nitro, hydroxy, cyano, halogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 cycloalkyl, substituted or unsubstituted C3-6 cycloalkylalkyl, and substituted or unsubstituted C3-6 cycloalkenyl; or any two of Re, Rf, Rg, Rh, Rj, Rk, Rl may be joined to form (i) a substituted or unsubstituted, saturated or unsaturated 3-14 membered ring, which may optionally include one or more heteroatoms which may be the same or different and are selected from O, NR′ (where R′ is H or alkyl) or S, or (ii) an oxo (═O), thio (═S) or imino (═NR′) (where R′ is H or alkyl); and each of r, s, t and u is 0, 1 or 2 with the proviso that r+s+t+u≠0. |
