| 主权项 |
1. A compound having the structure of any one of formulae (8) to (13), or a stereoisomer, isotopic form, or pharmaceutically acceptable salt thereof:wherein
X is N; X1 is O or S; R3 is hydrogen, deuterium, alkoxy, cyano, amino, hydroxyl, halogen, nitro, carbonyl, carboxy, amido, trifluoromethyl, trihaloalkyl, trifluoroalkoxy or a C1-8 substituted or unsubstituted alkyl, alkenyl or alkynyl; R4 is hydrogen, alkoxy, cyano, amino, hydroxyl, halogen, nitro, carbonyl, carboxy, amido, trifluoromethyl, trihaloalkyl, trifluoroalkoxy or a C1-8 substituted or unsubstituted alkyl, alkenyl or alkynyl, R5 is hydrogen or —P(O)(ORx)(ORy) wherein each of Rx and Ry independently is hydrogen, alkoxy, cyano, amino, hydroxyl, halogen, nitro, carbonyl, carboxy, amido, trifluoromethyl, trihaloalkyl, trifluoroalkoxy or a C1-8 substituted or unsubstituted alkyl, alkenyl or alkynyl; or R4 and R5 together form —O—(P—)(O)(OR7) wherein R7 is selected from the group consisting of hydrogen, trifluoromethyl, trihaloalkyl or a C1-8 substituted or unsubstituted alkyl, alkenyl or alkynyl and salts; A is hydrogen, deuterium or optionally substituted (C1-C20)alkyl, (C3-C20)cycloalkyl, (C3-C18)cycloalkyl(C1-C18)alkyl, (C6-C24)aryl, (C7-C25)aralkyl, (C2-C18)alkenyl, (C8-C26)aralkenyl, (C2-C18)alkynyl, (C8-C26)aralkynyl, heterocyclic or optionally substituted sulfonamide; R1 is hydrogen, deuterium or optionally substituted (C1-C18)alkyl, (C3-C18)cycloalkyl, (C3-C18)cycloalkyl(C1-C18)alkyl, (C6-C24)aryl, (C7-C25)aralkyl, (C2-C18)alkenyl, (C8-C26)aralkenyl, (C2-C18)alkynyl, (C8-C26)aralkynyl, (C8-C26)polycycloalkyl, substituted or unsubstituted heterocyclic, substituted or unsubstituted heteroaryl, substituted C1-20alkyl, C3-20 cycloalkyl substituted aryl, C3-20 cycloalkyl substituted heteroaryl, heteroaryl substituted C2-20 alkenyl, heteroaryl substituted C2-20 alkynyl, aryl substituted alkoxyl, C3-20 cycloalkyl substituted aryl alkoxyl, alkylaryl substituted alkoxyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryloxy, fused 4-5, 4-6, 5-5, 5-6 or 6-6 heterobicylic ring system, or a group (a-d), wherein Ar is an optionally substituted 5-12 atom aromatic or heteroaromatic ring system; B, C, D, E and F are independently selected from C(R)n, O, S(O)n, and N(R)n; G and H are independently hydrogen, deuterium or optionally substituted (C1-C20)alkyl, (C3-C20)cycloalkyl, (C3-C18)cycloalkyl(C1-C18)alkyl, (C6-C24)aryl, (C7-C25)aralkyl, (C7-C18)alkenyl, (C8-C26)aralkenyl, (C2-C18)alkynyl, (C826)aralkynyl, optionally substituted sulfonamide, (C8-C26)polycycloalkyl, substituted or unsubstituted heterocyclic, substituted or unsubstituted heteroaryl, C3-20 cycloalkyl substituted aryl, C3-20 cycloalkyl substituted heteroaryl, heteroaryl substituted C2-20 alkenyl, heteroaryl substituted C2-20 alkenyl, aryl substituted alkoxyl, C3-20 cycloalkyl substituted aryl alkoxyl, alkylaryl substituted alkoxyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryloxy, or fused 4-5, 4-6, 5-5, 5-6 or 6-6 heterobicylic ring system; Q and Q1 are independently represented by —{C(R)2}m—X′—*, the asterisk indicating the bond that is linked to the phenyl ring of any one of formulae (8) to (13), m is 0-5; X′ is C(R)n, N(R)n, O, S(O)n or C(O) in groups (b) and (c); X′, Y and Z are independently C(R)n″, or N in group (d); R is hydrogen, deuterium, alkoxy, cyano, amino, hydroxyl, halogen, nitro, carbonyl, carboxy, amido, trifluoromethyl, trihaloalkyl, trifluoroalkoxy or a C1-8 substituted or unsubstituted alkyl, alkenyl or alkenyl; R′ and R′1 are independently hydrogen, deuterium, alkoxy, cyano, amino, hydroxyl, halogen, nitro, carbonyl, carboxy, amido, trifluoromethyl, trihaloalkyl, trifluoroalkoxy or a C1-8 substituted or unsubstituted alkyl, alkenyl or alkynyl; n is 0-2; and n″ is 0-1. |
