TEM8 antibodies, conjugates thereof, and their use

摘要

Antibodies that specifically bind TEM8 protein, and conjugates thereof, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.

主权项

1. An isolated monoclonal antibody or antigen binding fragment thereof, comprising a heavy chain variable region comprising a heavy chain complementarity determining region (HCDR)1, a HCDR2, and a HCDR3, and a light chain variable region comprising a light chain complementarity determining region (LCDR)1, a LCDR2, and a L-CDR3, of the amino acid sequences set forth as one of:
(a) SEQ ID NO: 1 and SEQ ID NO: 6, respectively (L2); (b) SEQ ID NO: 2 and SEQ ID NO: 7, respectively (L1); (c) SEQ ID NO: 3 and SEQ ID NO: 8, respectively (L3); (d) SEQ ID NO: 4 and SEQ ID NO: 9, respectively (L5); or (e) SEQ ID NO: 5 and SEQ ID NO: 10, respectively (1D2); and wherein the monoclonal antibody or antigen binding fragment specifically binds to TEM8.