| 主权项 |
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein, independently for each occurrence: at least two R1 taken together form an oxo group; wherein additional R1 groups are selected from the group consisting of C1-C6 alkyl, C1-C6 fluoroalkyl, C3-C8 cycloalkyl, halo, NR8SO2R8, SO2R8, SR8, SOR8, NR8COR8, NR8CO2R8, CN, CON(R8)2, SO2N(R8)2, CF3, optionally substituted heterocycloalkyl, phenyl, heteroaryl, and a straight chain, branched, or cyclic (C3-C8)-R9-wherein up to two CH2 units may be replaced with O, CO, S, SO, SO2, N, CF2, or NR8; R2 is H, C1-C6 alkyl, C1-C6 fluoroalkyl, an optionally substituted cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, COR8, CO2R8, CON(R8)2, CF3, CHF2, or a straight chain, branched, or cyclic (C3-C8)-R9-wherein up to two CH2 units may be replaced with O, CO, S, SO, SO2, N, CF2, or NR8; R3 is C1-C6 alkyl or halo; R8 is H, C1-C6 alkyl, or C3-C8 cycloalkyl, a straight chain, branched, or cyclic (C3-C8)-R9-wherein up to two CH2 units may be replaced with O, CO, S, SO, SO2, N, CF2, or NR, or 2 R8 taken together with the atoms to which they are attached form a ring; R9 is H, CF3, CHF2, CH2F, CO2R, OH, optionally substituted aryl, heteroaryl, C3-C8 cycloalkyl, heterocycloalkyl, N(R)2, NRCOR, CON(R)2, CN, or SO2R; R is H, C1-C6 alkyl, optionally substituted aryl, heteroaryl, C3-C8 cycloalkyl, or heterocycloalkyl; A is aryl, heteroaryl or heterocyclic in which each is optionally substituted with C1-C6 alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkoxy, C1-C6 alkoxy, halo, CN, OH, OR8, N(R8)2, NR8SO2R8, SO2R8, SOR8, SR8, CO2R8, NR8COR8, NR8CO2R8, CON(R8)2, SO2N(R8)2, CHF2, CF3, OCF3, OCHF2, R9, heterocycloalkyl, heterocycloalkoxy, aryl, heteroaryl, or a straight chain, branched, or cyclic (C3-C8)-R9 wherein up to three CH2 units may be replaced with O, CO, S, SO, SO2, N, CF2, or NR8; n is an integer from 3 or 4; and o is an integer from 0, 1, 2, 3, or 4. |
