Methods for fabricating nano and microparticles for drug delivery

摘要

The present invention generally relates to stimuli-responsive drug carriers and methods for making. More specifically, the present invention relates to stimuli-responsive lidded particles that respond to a physiological stimulus and dissolve at a target site inside the body thereby releasing therapeutic agents. The present invention further relates to solid, drug-loaded particles that are made from biodegradable polymers. The present invention further relates to methods for fabricating lidded particles and particles for drug delivery.

主权项

1. A method for making a plurality of monodisperse, solid particles comprising:
placing, on a silicon substrate, a patternable biodegradable polymer comprising a therapeutic agent, an imaging contrast agent, or both incorporated into a polymer matrix of the polymer; placing a release layer on an imprint template; imprinting the polymer by pressing the release layer and imprint template into the polymer, thereby forming a plurality of monodisperse, solid particles between 50 nm and 1000 nm in size corresponding to a plurality of particle-shaped portions of the imprint template and containing the therapeutic agent, an imaging contrast agent, or both, and also forming a residual polymer layer on the silicon substrate; removing the imprint template; oxygen plasma cleaning the plurality particles and residual polymer layer on the silicon substrate to remove the residual polymer layer; and releasing the plurality of particles.