Neurodegenerative diseases and methods of modeling

摘要

This invention relates to methods for neuroprotection, promoting survival of motor neurons and the treatment of motor neuron diseases by preventing cell signaling through the classic prostaglandin D2 receptor DP1.

主权项

1. A method of treating motor neuron disease, the method comprising administering an inhibitor of a prostaglandin D2 DP1 receptor comprising the compound of formula (II) to a subject in need thereof, wherein the inhibitor inhibits expression or activity the prostaglandin D2 DP1 receptor, wherein the motor neuron disease is amyotrophic lateral sclerosis (ALS), and wherein: R1 is H or C1-C6 alkyl; R2 is aryl or heteroaryl, each of which can be optionally substituted; R3 and R4 are each independently is halo, —CF3, —CN, —NO2, —S(═O)alkyl, —SO2alkyl, C1-C6 alkyl; —C(O)alkyl, —CH(OH)alkyl; and m is 1, 2 or 3.