发明名称 <i>Cassia </i>derivatives
摘要 This invention relates to a cationically and amphiphilically modified polygalactomannan having repeating units with an average D-mannosyl to D-galactosyl residue ratio of at least 5 to 1 and to compositions containing same. A portion of the hydrogen atoms of hydroxyl groups situated on the mannosyl and galactosyl residues of the galactomannan are replaced with an amphiphilic and a cationic substituent.
申请公布号 US9180084(B2) 申请公布日期 2015.11.10
申请号 US201214125190 申请日期 2012.05.17
申请人 Lubrizol Advanced Materials, Inc. 发明人 Lepilleur Carole A.;Malaba Dennis;Mullay John J.;Rafferty Denise W.;Krzysik Duane G.;Liu Xin;Anderson Eric H.
分类号 A61K8/73;A61Q5/02;A61Q5/06;C08B37/00;C08L5/00;A61Q5/12;A61K8/97;C11D3/22;A61Q5/00;A61Q5/10;A61Q7/00;A61Q11/00;A61Q15/00;A61Q17/04;A61Q19/02;A61Q19/04;A61Q19/06;A61Q19/08 主分类号 A61K8/73
代理机构 代理人 Dunlap Thoburn T.
主权项 1. A cationically and amphiphilically modified galactomannan having an average mannose to galactose ratio of at least 5:1 wherein a portion of the hydrogen atoms of the hydroxyl groups present on the galactomannan are substituted with a least one cationic moiety represented by formula (I) and at least one amphiphilic moiety represented by formula (II) as follows: wherein A, independently, is selected from a divalent linear or branched, substituted or unsubstituted C1-C6 alkylene radical, and when substituted said substituent, independently, is selected from hydroxyl and halo; R, independently, is selected from —S+R3R4 X−, —N+R3R4R5 X−, and —P+R3R4R5 X−, wherein R3 and R4, and R5, independently, are selected from hydrogen and linear and branched C1-C24 alkyl, and X− represents an anion; (R1—O)c represents a oxyalkylene moiety or a polyoxyalkylene moiety arranged as a homopolymer, a random copolymer or a block copolymer of oxyalkylene units, wherein R1, independently, is selected from linear and branched C2H4, C3H6, and C4H8 divalent alkylene groups, and c is an integer ranging from about 2 to about 250; R2, independently, is selected from a hydrocarbon group having from about 6 to about 35 carbon atoms; a is 0 or 1; and b is 0 or 1, subject to the proviso that when a is 0, then b is also 0.
地址 Cleveland OH US