formulação farmacêutica veterinária que inclui uma partícula recombinante de rna que codifica para uma proteína cu/zn superóxido dismutase de bactérias patogênicas de ruminantes e pelo menos um alfavírus rna pertencente à família do vírus semliki forest

摘要

The technology is a veterinary pharmaceutical formulation of two vaccines, one from an RNA viral vector system constituted by an RNA recombinant particle that codifies for a Cu/Zn superoxide dismutase protein of Brucella abortus, and the other based on naked RNA constituted by a recombinant molecule of naked RNA that carries a sequence for the synthesis of at least one recombinant Cu/Zn superoxide dismutase protein of Brucella abortus and some Semliki Forest virus genes. An expression system based on the Semliki Forest virus and a use of this system, in addition to a method for the preparation of the pharmaceutical formulations.