Use of non-labeled sugars and detection by MRI for assessing tissue perfusion and metabolism

摘要

A method for magnetic resonance (MR) imaging or spectroscopy on a MR scanner to detect tissue physiological parameters in one or more tissue areas in a human or non-human subject includes administering to the subject a contrast enhancing physiologically tolerable amount of a sugar that is non-labeled, subjecting the subject to an MR procedure capable of generating MR signals encoding at least one tissue area in the subject in which the sugar either passes or is taken up, detecting a temporal variation in the MR signals in the at least one tissue area after the administering the sugar, determining at least one tissue-related parameter from the temporal variation, and ascertaining whether the at least one tissue-related parameter is abnormal.

主权项

1. A method for magnetic resonance (MR) imaging or spectroscopy on a MR scanner to detect tissue physiological parameters in one or more tissue areas in a human or non-human subject, comprising:
administering to said subject a contrast enhancing physiologically tolerable amount of a sugar that is non-labeled; subjecting said subject to an MR procedure capable of generating MR signals encoding at least one tissue area in said subject in which said sugar either passes or is taken up; detecting a temporal variation in said MR signals in said at least one tissue area after said administering said sugar, wherein said sugar is at least one of a synthetic or naturally occurring sugar, including D-glucose or L-glucose, its polymers or any other biocompatible sugar containing one or more hydroxyl groups or other exchangeable groups and their isomers; determining at least one tissue-related parameter from said temporal variation; and ascertaining whether said at least one tissue-related parameter is abnormal.