Slow-release cilostazol tablet having an improved elution rate and minimal side effects

摘要

Provided is a slow-release tablet including cilostazol as a pharmacologically active component, which is efficacious in suppressing aggregation of blood platelets and promoting vascular relaxation by inhibiting phosphodiesterase types. The slow-release cilostazol tablet has an extended elution time so that the slow-release cilostazol tablet can be taken once daily for convenience of drug use, and minimizes the manifestation of headache which is one side effect caused when women, the elderly and children take conventional cilostazol preparations so that the convenience of drug use can be improved. Also, the slow-release cilostazol tablet exhibits a stable elution pattern with no variation in elution rate according to changes in pH in the stomach and intestines, as well as an effect of delaying the release of a drug, using a mixture of hydroxypropyl methylcellulose and a carbomer as a release-controlling polymer.

主权项

1. A slow-release cilostazol tablet comprising cilostazol, a release-controlling polymer, a binder, a filler and a lubricant,
wherein the release-controlling polymer is a 1.5:1 to 20:1 mixture of hydroxypropyl methylcellulose having a viscosity of 80,000 cps to 120,000 cps and a carbomer, wherein the tablet does not comprise a coating comprising a release-controlling polymer, and wherein the tablet has the following elution profiles according to a paddle method of 37+0.5° C., 0.5 W/W % sodium lauryl sulfate solution, 75 rpm; (a) the tablet releases 1.9% to 4.8% of the cilostazol after 15 minutes; (b) the tablet releases 20.3% to 31.2% of the cilostazol after 240 minutes; and (c) the tablet releases 89.1% to 100.8% of the cilostazol after 1440 minutes.