| 发明名称 |
Combination therapy of anti-HER3 antibodies |
| 摘要 |
The present invention relates to the combination therapy of anti-HER3 antibodies with certain anti-HER antibodies. |
| 申请公布号 |
US9180185(B2) |
申请公布日期 |
2015.11.10 |
| 申请号 |
US201414151626 |
申请日期 |
2014.01.09 |
| 申请人 |
Hoffman-La Roche Inc. |
发明人 |
Bauss Frieder;Bossenmaier Birgit;Friess Thomas;Gerdes Christian;Hasmann Max;Thomas Marlene;Weisser Martin |
| 分类号 |
A61K39/395;C07K16/28;C07K16/32;A61K39/00 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
Ropp Traci H. |
| 主权项 |
1. A method of treating a patient suffering from a HER2-normal cancer wherein the method comprises the co-administration of an antibody which binds to human HER3 in combination with an antibody which binds to human HER2 and which inhibits dimerization of HER2, wherein the antibody which binds to human HER3 comprises a heavy chain variable domain comprising a CDR3H region of SEQ ID NO: 1, a CDR2H region of SEQ ID NO: 2, and a CDR1H region of SEQ ID NO:3, and a light chain variable domain comprising a CDR3L region of SEQ ID NO: 4 a CDR2L region of SEQ ID NO:5, and a CDR1L region of SEQ ID NO:6 or a CDR1L region of SEQ ID NO:7. |
| 地址 |
Little Falls NJ US |
