发明名称 |
[1,2,4]triazolopyridines and their use as phosphodiesterase inhibitors |
摘要 |
The present invention relates to novel [1,2,4]triazolopyridine compounds with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions. |
申请公布号 |
US9181248(B2) |
申请公布日期 |
2015.11.10 |
申请号 |
US201414572218 |
申请日期 |
2014.12.16 |
申请人 |
LEO PHARMA A/S |
发明人 |
Nielsen Simon Feldbaek;Larsen Jens Christian Hojland |
分类号 |
A61K31/437;C07D471/04 |
主分类号 |
A61K31/437 |
代理机构 |
Birch Stewart Kolasch & Birch, LLP |
代理人 |
Birch Stewart Kolasch & Birch, LLP |
主权项 |
1. A method of treating dermal diseases or conditions, which method comprises the step of administering to person suffering from said disease or condition a therapeutically effective amount of tert-butyl 1-[8-methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate, optionally together with a pharmaceutically acceptable carrier or one or more excipients, wherein the dermal disease or condition is selected from the group consisting of dermatitis, atopic dermatitis, seborrheic dermatitis, contact dermatitis, psoriasis, acne, pruritis, eczema, COPD and asthma. |
地址 |
Ballerup DK |