| 主权项 |
1. A compound of formula (Ia)or a pharmaceutically acceptable salt thereof, wherein:
L1 is
a) C3-C7alkylene, C3-C7alkenylene, or C3-C7alkynylene, wherein the C3-C7alkylene, C3-C7alkenylene, or C3-C7alkynylene are each optionally substituted with 1, 2, 3, or 4 fluoro substituents;b) —(CH2)t-G-(CH2)p—; wherein t is 0, 1, or 2, p is 0, 1, 2, or 3, and t+p=0, 1, 2, 3, or 4; orc) —(CH2)n-G1-(CH2)p—, —(CH2)n-G2-(CH2)p—, —(CH2)n—C≡C-G2-, or —(CH2)n—C(R13)═C(R13)-G2-, wherein n is 1, 2, 3, 4, or 5, p is 0, 1, 2, or 3, and n+p=1, 2, 3, 4, 5, or 6; G is G1 is O, C(O), S, S(O), S(O)2, or NR8; wherein R8 is H, C1-C1 alkyl, or C1-C4alkylcarbonyl; G2 iswherein G2 is optionally substituted with 1, 2, or 3 substituents selected from the group consisting of C1-C4alkyl, C1-C3haloalkyl, cyano, halogen, C1-C3alkoxy, and C1-C3haloalkoxy;
R1 is COOR10, CONR10R11, CH2OR10, SO3R10, SO2NR10R11, PO(OR10)2, or tetrazol-5-yl; R10 is H, C1-C4 alkyl, or aryl; R11 is H, C1-C4 alkyl, COR12, OR10, or SO2R12; R12 is C1-C4 alkyl; R13, at each occurrence, is independently H or C1-C4alkyl; L4 is —C(R2)2—C(R3)2—, —C(R2)═C(R3)—, orwherein R2 and R3 are each H, CH3, fluoro, or chloro;
L2 is —CH2— or a bond; R4 and R5 are each independently H, F, CF3, or C1-C4 alkyl; or R4 and R5 together with the carbon to which they are attached form a C3-C5 cycloalkyl, R6 is aryl, heteroaryl, C3-C10alkyl, C3-C10alkenyl, C3-C10alkynyl, C3-C10haloalkyl, C3-C10haloalkenyl, C3-C10haloalkynyl, or L3-R7; wherein the aryl and heteroaryl are optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C1-C4alkyl, C1-C3haloalkyl, cyano, halogen, C1-C3alkoxy, C1-C3haloalkoxy; and —C1-C3alkylene-C1-C3alkoxy; and wherein the C3-C10alkyl, C3-C10alkenyl, C3-C10alkynyl, C3-C10haloalkyl, C3-C10haloalkenyl, and C3-C10haloalkynyl are optionally substituted with a substituent selected from the group consisting of COOR10′, CONR10′R11′, CH2OR10′, SO3R10′, SO2NR10′R11′, PO(OR10′)2, and tetrazol-5-yl; R10′ is H, C1-C4 alkyl, or aryl; R11′ is H, C1-C4 alkyl, COR12′, OR10′, or SO2R12′; R12′ is C1-C4 alkyl; L3 is C1-C6alkylene, C2-C6alkenylene, C2-C6alkynylene, —(CH2)m-G3-(CH2)q—, —(CH2)m-G4 (CH2)q—, or -G5-C≡C—; wherein the C1-C6alkylene, C2-C6alkenylene, and C2-C6alkynylene are optionally substituted with 1, 2, 3, or 4 fluoro substituents; and wherein m and q are each independently 0, 1, 2, or 3 and m+q=0, 1, 2, 3, or 4; G3 is O, C(O), S, S(O), S(O)2, or NR9; wherein R9 is H, C1-C4 alkyl, or C1-C4alkylcarbonyl; G4 iswherein G4 is optionally substituted with 1, 2, or 3 substituents selected from the group consisting of C1-C4alkyl, C1-C3haloalkyl, cyano, halogen, C1-C3alkoxy, and C1-C3haloalkoxy;
G5 iswherein G5 is optionally substituted with 1, 2, or 3 substituents selected from the group consisting of C1-C4alkyl, C1-C3haloalkyl, cyano, halogen, C1-C3alkoxy, and C1-C3haloalkoxy;
R7 is C3-C8cycloalkyl, aryl, heteroaryl, or heterocyclyl; wherein R7 is optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C1-C4alkyl, C1-C3haloalkyl, cyano, halogen, C1-C3alkoxy, C1-C3haloalkoxy, and —C1-C3alkylene-C1-C3alkoxy; r is 0 or 1; and s is 0 or 1. |
