Intermediates for macrocyclic compounds

摘要

The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates:;
wherein R1, R2, R3, R4, R5, R6, n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.

主权项

1. A compound of formula W-T-Y, wherein W and Y are independently selected from the group consisting of —OH, —NH2 and —NHR60, wherein R60 is lower alkyl, and T is the following structure: wherein L5 is CH or N; L6 is CR52R53 or O, wherein R52 and R53 are independently selected from the group consisting of hydrogen and lower alkyl; R54 and R55 are independently lower alkyl; and, when L6 is CR52R53, R55 is also selected from hydroxy; R56 is hydrogen or lower alkyl, and R57 is selected from the group consisting of hydrogen and lower alkyl, and, when no double bond is present between the carbon atoms to which R56 and R57 are bonded, R56 and R57 are also independently selected from hydroxy; and (W) indicates the point of attachment of T to W; and (Y) indicates the point of attachment of T to Y; with the proviso that T is not the following: further comprising one or more protecting groups.