Nanocrystal nano-emulsion

摘要

A nanocrystal formulation in the form of a nano-emulsion includes a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase has at least one amphiphilic lipid and at least one solubilising lipid, and in which the aqueous phase has a cosurfactant. The invention also relates to a method for the production of the formulation as well as uses within the fields of medical imaging, thermotherapy or phototherapy.

主权项

1. A formulation of metal, metal oxide or semi-conductor nanocrystals in the form of a nano-emulsion, comprising a continuous aqueous phase and at least one dispersed oily phase encapsulating the nanocrystals, wherein a surface of the dispersed oily phase has a zeta potential having an absolute value lower than 20 mV,
wherein the oily phase comprises:
at least one phospholipid, andat least one solubilising lipid consisting of a mixture of saturated fatty acids glycerides comprising:
at least 10% by weight C12 fatty acids,at least 5% by weight C14 fatty acids,at least 5% by weight C16 fatty acids andat least 5% by weight C18 fatty acids, wherein the aqueous phase comprises a cosurfactant, and wherein the cosurfactant comprises at least one chain formed of ethylene oxide units or ethylene oxide and propylene oxide units.