发明名称 Substituted <i>N</i>-phenethyltriazoloneacetamides and use thereof
摘要 The present application relates to novel substituted N-phenethyltriazoloneacetamides, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
申请公布号 US9180120(B2) 申请公布日期 2015.11.10
申请号 US201113818337 申请日期 2011.08.31
申请人 Bayer Intellectual Property GmbH 发明人 Fürstner Chantal;Keldenich Joerg;Delbeck Martina;Kolkhof Peter;Kretschmer Axel;Pook Elisabeth;Schmeck Carsten;Trübel Hubert
分类号 A61K31/41;A61K31/4196;C07D249/12;C07D409/04;A61K45/06 主分类号 A61K31/41
代理机构 代理人 King Karen B.
主权项 1. A compound of formula (I) in which R1 represents (C1-C4)-alkyl or (C2-C4)-alkenyl, each of which may be mono- or disubstituted by identical or different radicals selected from the group consisting of fluorine, trifluoromethyl, hydroxy, methoxy and ethoxy, or represents benzyl which may be substituted in the phenyl ring by a radical selected from the group consisting of fluorine, chlorine, methyl, trifluoromethyl and methoxy, orrepresents cyclopropyl, R2 represents phenyl or thienyl which are substituted by a radical selected from the group consisting of fluorine and chlorine, R3A and R3B independently of one another represent hydrogen, fluorine, chlorine, methyl, trifluoromethyl, methoxy or trifluoromethoxy, but where at least one of the radicals R3A and R3B is different from hydrogen, R3C represents hydrogen, and L represents a group of the formula  in which * represents the point of attachment to the adjacent nitrogen atom and** represents the point of attachment to the phenyl ring,n represents the number 0 or 1, andR5 represents a group of the formula —O—C(═O)—NHR7B, —NH—C(═O)—NHR7B, —NH—C(═O)—R9, —NH—SO2—R10 or —NH—C(═O)—OR10 in which R7B represents hydrogen or (C1-C4)-alkyl,R9 represents hydrogen or (C1-C4)-alkyl, andR10 represents (C1-C4)-alkyl, or a salt thereof.
地址 Mcnheim DE