CRYSTALLINE ?-MODIFICATION OF N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUOR-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROL-3-CARBOXAMIDE MALATE, METHOD FOR PRODUCING SAME AND BASED PHARMACEUTICAL COMPOSITION

摘要

FIELD: medicine.SUBSTANCE: invention refers to a new crystalline ?-modification of N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluor-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-carboxamide malate, to a method for producing it and using the same for preparing a pharmaceutical composition as an antitumour agent, tyrosine kinase inhibitor for treating oncological diseases.EFFECT: more effective use of the compositions.4 cl, 6 dwg, 3 tbl, 5 ex