发明名称 |
análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente. |
摘要 |
An insulin analogue comprising a B-chain polypeptide incorporating a halogenated phenylalanine at position B24, B25 or B26. The analogue may be of a mammalian insulin such as human insulin. A nucleic acid encoding such an insulin analogue. Some halogenated insulin analogues retain significant activity. Medical uses of the insulin analogues for treating a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. Halogen substitution-based stabilisation of insulin may enhance the treatment of diabetes mellitus in regions of the developing world lacking refrigeration. The preferred analogue is an insulin analogue comprising a B-chain polypeptide incorporating a pentafluoro-phenylalanine (5F-Phe) at position B24. |
申请公布号 |
BRPI0916560(A2) |
申请公布日期 |
2015.11.10 |
申请号 |
BR2009PI16560 |
申请日期 |
2009.07.31 |
申请人 |
CASE WESTERN RESERVE UNIVERSITY |
发明人 |
MICHAEL WEISS |
分类号 |
A61K38/28;C07K14/62;C12N15/17 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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