发明名称 |
Lateral flow immunoassay for complement activation and methods of use for point-of-care assessment of complement-associated disorders |
摘要 |
A method for treating an individual at risk for a complement-associated disorder is provided, including: (a) obtaining a sample of a body fluid from the individual; (b) measuring a complement activation level in the sample via a point-of-care lateral flow immunoassay; (c) correlating the complement activation level in the sample to a risk of a complement-associated disorder by comparing the complement activation level in the sample to a reference level in a control, wherein a deviation in complement activation level in the sample compared to the reference level in the control indicates the individual is at risk for a complement-associated disorder; (d) selecting a treatment for the individual, based on the correlating of step (c); and (e) treating the individual with the treatment selected in accordance with step (d). Lateral flow immunoassays and a method of monitoring an individual suffering from a complement-associated disorder are also provided herein. |
申请公布号 |
US9182396(B2) |
申请公布日期 |
2015.11.10 |
申请号 |
US201113287432 |
申请日期 |
2011.11.02 |
申请人 |
Kypha, Inc. |
发明人 |
Olson Paul;Moss Don W. |
分类号 |
A61K39/395;G01N33/00;G01N33/53;G01N33/566;G01N33/564;G01N33/558;G01N33/86 |
主分类号 |
A61K39/395 |
代理机构 |
Choate, Hall & Stewart LLP |
代理人 |
Choate, Hall & Stewart LLP |
主权项 |
1. A lateral flow immunoassay for the point-of-care detection of a marker of complement activation in a body fluid sample comprising complement proteins, the lateral flow immunoassay comprising:
a membrane strip; a detecting antibody that binds a first epitope of the marker; a test line comprising a capturing antibody that binds a second epitope of the marker; and a control line comprising an antibody that binds a control analyte,wherein the marker is iC3b. |
地址 |
St. Louis MO US |