| 发明名称 | Variant LovD polypeptides and their uses | ||
| 摘要 | The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound. | ||
| 申请公布号 | US9181570(B2) | 申请公布日期 | 2015.11.10 |
| 申请号 | US201414465467 | 申请日期 | 2014.08.21 |
| 申请人 | Codexis, Inc. | 发明人 | Gilson Lynne;Collier Steven J.;Sukumaran Joly;Yeo Wan Lin;Alvizo Oscar;Teo Ee Ling;Wilson Robert J.;Xu Junye |
| 分类号 | C12N9/10;C12P21/06;C12N1/20;C12N15/00;C07H21/04;C12P17/06;C07K14/00;C12P7/62 | 主分类号 | C12N9/10 |
| 代理机构 | Codexis, Inc. | 代理人 | Codexis, Inc. |
| 主权项 | 1. An isolated recombinant variant LovD polypeptide having at least two-fold greater acyltransferase activity than the wild-type Aspergillus terreus acyltransferase, wherein said variant LovD polypeptide is at least 90% sequence identity to SEQ ID NO:2, wherein said variant LovD polypeptide comprises the substitution L174F, wherein the positions is numbered by correspondence with the amino acid sequence set forth in SEQ ID NO:2. | ||
| 地址 | Redwood City CA US | ||