| 发明名称 | Conjugated antisense compounds and their use | ||
| 摘要 | Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine. | ||
| 申请公布号 | US9181549(B2) | 申请公布日期 | 2015.11.10 |
| 申请号 | US201414586751 | 申请日期 | 2014.12.30 |
| 申请人 | Isis Pharmaceuticals, Inc. | 发明人 | Prakash Thazha P.;Seth Punit P.;Swayze Eric E. |
| 分类号 | C07H21/02;C07H21/04;C12N15/13;C12N15/113;C12N15/11 | 主分类号 | C07H21/02 |
| 代理机构 | Hoxie and Associates, LLC | 代理人 | Hoxie and Associates, LLC |
| 主权项 | 1. A compound having the formula (XXVI): wherein: T2 is a group comprising a conjugate linker, a cleavable moiety, and an oligomeric compound. | ||
| 地址 | Carlsbad CA US | ||