| 发明名称 | Antigen associated with the neovasculature of tumour metastases | ||
| 摘要 | The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumor metastases. | ||
| 申请公布号 | US9181347(B2) | 申请公布日期 | 2015.11.10 |
| 申请号 | US201313935171 | 申请日期 | 2013.07.03 |
| 申请人 | Philogen S.p.A. | 发明人 | Rybak Jascha-Nikolai;Rosli Christoph;Villa Alessandra;Neri Giovanni;Neri Dario |
| 分类号 | A61K39/42;A61K39/395;A61K39/44;C07K16/30;A61K51/10;C07K16/18;A61K39/00 | 主分类号 | A61K39/42 |
| 代理机构 | Klarquist Sparkman, LLP | 代理人 | Klarquist Sparkman, LLP |
| 主权项 | 1. An isolated nucleic acid encoding an antibody, or an antigen binding fragment thereof, that binds the Extra Domain-A (ED-A) of fibronectin, comprising a VH domain comprising three complementarity determining regions (CDRs) comprising the amino acid sequences of SEQ ID NO: 83, SEQ ID NO: 4 and SEQ ID NO: 5 and a VL domain comprising amino acid residues 1-108 of SEQ ID NO: 82. | ||
| 地址 | Siena IT | ||