发明名称 Salts of sitagliptin, process for the preparation and pharmaceutical composition therefore
摘要 The present invention relates to pharmaceutically acceptable acid addition salts of sitagliptin, in particular anti-oxidant acid addition salts of sitagliptin and a process for its preparation. The present invention also provides a pharmaceutical composition using the pharmaceutically acceptable acid addition salts of sitagliptin.
申请公布号 US9181256(B2) 申请公布日期 2015.11.10
申请号 US201213985490 申请日期 2012.10.12
申请人 Laurus Labs Private Ltd. 发明人 Indukuri Venkata Sunil Kumar;Gorantla Seeta Ramanjaneyulu;Muppidi Vamsee Krishna;Chava Satyanarayana
分类号 C07D487/04;A61K31/4985;C07C57/42 主分类号 C07D487/04
代理机构 Blank Rome LLP 代理人 Blank Rome LLP
主权项 1. An anti-oxidant acid salt of sitagliptin, or solvates or hydrates thereof, wherein the anti-oxidant acid is selected from the group consisting of caffeic acid, ferulic acid, and p-coumaric acid, and wherein the caffeic acid salt of sitagliptin is characterized by a X-ray diffraction (XRD) pattern in accordance with FIG. 1, FIG. 2, FIG. 3, FIG. 4, FIG. 5, FIG. 6, or FIG. 7, the ferulic acid salt of sitagliptin is characterized by a XRD pattern in accordance with FIG. 8, FIG. 9, FIG. 10, FIG. 11, FIG. 12, or FIG. 13, and the p-coumaric acid salt of sitagliptin is characterized by a XRD pattern in accordance with FIG. 14, FIG. 15, FIG. 16, FIG. 17, FIG. 18, FIG. 19, or FIG. 20.
地址 Hyderabad IN