Adjustable balloon catheter for extravasated drug delivery

摘要

An adjustable balloon catheter for extravasated drug delivery is disclosed generally including an outer catheter with a first balloon and an inner catheter with a second balloon. The inner catheter is moveably disposed in a lumen of the outer catheter such that the inner catheter moves relative to the outer catheter, changing the distance between the balloons. A fluid source supplies air to the catheters via lumens therein to inflate the balloons to create a chamber between them, and at least one of the catheters has a lumen for delivering a therapeutic and/or diagnostic agent to the chamber. The inner catheter is then moved relative to the outer catheter to decrease the size of the chamber between the balloons and decrease the fluid pressure therein such that the therapeutic and/or diagnostic agent is extravasated into the surrounding tissue.

主权项

1. A method of delivery of a therapeutic and/or diagnostic agent to tissue, the method comprising:
inserting a catheter assembly into a bodily cavity, the catheter assembly comprising
an outer catheter having a lumen therein, an outer wall, and a first balloon, andan inner catheter at least partially disposed in the lumen of the outer catheter, the inner catheter having an outer wall and and a second balloon; inflating the first and second balloons by supplying fluid thereto to create a chamber between the first balloon and the second balloon, said chamber having a volume; delivering the therapeutic and/or diagnostic agent through at least one opening in at least one of the outer walls of the inner and outer catheters positioned between the first and second balloons to the chamber between the first and second balloons; and increasing the fluid pressure within the chamber containing the therapeutic and/or diagnostic agent by moving at least one of the first and second balloons toward the other of the first and second balloons to decrease the volume of the chamber.