发明名称 |
TARGETED LYSOSOMAL ENZYME COMPOUNDS |
摘要 |
<p>The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, where compound is a fusion protein including iduronate-2-sulfatase and Angiopep-2. In certain embodiments, these compounds, owning to the presence of the targeting moiety can crossing the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also features methods for treating lysosomal storage disorders (e.g., mucopolysaccharidosis Type II) using such compounds.</p> |
申请公布号 |
HK1204002(A1) |
申请公布日期 |
2015.11.06 |
申请号 |
HK20150104430 |
申请日期 |
2015.05.11 |
申请人 |
ANGIOCHEM INC. |
发明人 |
BOIVIN, DOMINIQUE;CASTAIGNE, JEAN-PAUL;DEMEULE, MICHEL;TRIPATHY, SASMITA;CURRIE, JEAN-CHRISTOPHE;LORD-DUFOUR, SIMON |
分类号 |
C12N;A61K;A61P;C07K |
主分类号 |
C12N |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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