发明名称 |
CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE |
摘要 |
A compound represented by the general formula:
or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C 6-14 aryl group or the like, L is -NR e CO- or the like (wherein R e is a hydrogen atom or the like), Ring B is a C 6-14 aryl group or the like, X is a C 1-3 alkylene group or the like, Y is a single bond or the like, Z is a C 1-3 alkylene group or the like, R 1 and R 2 are each independently a hydrogen atom or the like, and R 3 , R 4 , R 5 and R 6 are independently a hydrogen atom, a halogen atom or the like, has an A² production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by A² and typified by Alzheimer-type dementia. |
申请公布号 |
HRP20151030(T1) |
申请公布日期 |
2015.11.06 |
申请号 |
HR2015P001030T |
申请日期 |
2015.09.29 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
SUZUKI, YUICHI;MOTOKI, TAKAFUMI;KANEKO, TOSHIHIKO;TAKAISHI, MAMORU;ISHIDA, TASUKU;TAKEDA, KUNITOSHI;KITA, YOICHI;YAMAMOTO, NOBORU;KHAN, AFZAL;DIMOPOULOS, PASCHALIS |
分类号 |
C07D279/08;A61K31/4439;A61K31/5415;A61K31/542;A61P25/28;A61P43/00;C07D417/10;C07D417/12;C07D417/14;C07D513/04 |
主分类号 |
C07D279/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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