| 摘要 |
Presented herein are polymeric cellular dosage forms exhibiting improved immediate release properties, while maintaining high uniformity and satisfactory mechanical properties (e.g., to permit necessary handling). An exfoliating polymeric cellular dosage form is described herein that can be cost-effectively manufactured via batch or even non-batch (continuous or semi-continuous) melt processing. The solid dosage forms have a unique cellular microstructure featuring a number of open, interconnected cells. The cell walls contain the active ingredient(s) as well as an excipient that swells in the presence of a physiological fluid such as gastrointestinal fluid and/or saliva under physiological conditions. |
