BIODEGRADABLE MEDICAL DEVICE HAVING AN ADJUSTABLE DEGRADATION RATE AND METHODS OF MAKING THE SAME

摘要

Disclosed herein are biodegradable medical devices comprising biodegradable materials (e.g., magnesium-calcium alloys) having an adjustable rate of degradation that can be used in various applications including, but not limited to, drug delivery applications, cardiovascular applications, and orthopedic applications to make biodegradable and biocompatible devices. Also disclosed herein are methods of making biodegradable medical devices comprising biodegradable materials by using, for instance, hybrid dry cutting/hydrostatic burnishing.

主权项

1. A non-peened biodegradable medical device with custom degradation kinetics and topography comprising:
a non-peened biodegradable material made from a biodegradable implant material and an alloying element; wherein the biodegradable implant material includes magnesium; wherein the alloying element includes calcium and is present in an amount of 0.8 percent by weight; and wherein the biodegradable medical device has a degradation rate of from 0.001 millimeters per year to 20 millimeters per year in an environment having a pH of 7.5 or less; wherein the biodegradable medical device has a maximum residual stress on or below the surface of from −170 megapascals to −20 megapascals; wherein the biodegradable medical device has a maximum hardness on or below the surface of from 40 HV to 140 HV; wherein the biodegradable medical device has a grain size of from 100 micrometers to 700 micrometers; and wherein the biodegradable medical device has a surface roughness of from 0.1 micrometers to 10 micrometers.