发明名称 ANTI-MUC1 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF AND USES THEREOF
摘要 The present invention provides: an antibody exhibiting specificity for MUC1, the antibody having a glycan structure expressed at high levels in cancer cells; a method for manufacturing this antibody; and a novel means and method for the diagnosis and prevention and/or treatment of cancer using this antibody. The present invention is a monoclonal antibody to human MUC1, wherein the antibody specifically recognizes a glycopeptide having a human MUC1 tandem unit and furthermore having an O-linked glycan core (0(Tn)) in any one of the threonine and serine in the amino acid sequence of this human MUC1 tandem unit. A method for detecting MUC1 in a human body-fluid sample. A kit including this monoclonal antibody. A pharmacological composition for the prevention and/or treatment of a malignant tumor, the pharmacological composition containing this monoclonal antibody as an active ingredient.
申请公布号 CA2947404(A1) 申请公布日期 2015.11.05
申请号 CA20152947404 申请日期 2015.04.28
申请人 MEDICINAL CHEMISTRY PHARMACEUTICALS, CO., LTD. 发明人 NISHIMURA, SHINICHIRO;MIYOSHI, RISHO;NARUCHI, KENTARO;TANAKA, MASAKAZU;SATO, MASAHARU
分类号 C07K16/28;A61K39/395;A61P35/00;C12P21/08;C12Q1/02;G01N33/574 主分类号 C07K16/28
代理机构 代理人
主权项
地址