| 发明名称 |
METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF CKAP5 BY DOUBLE-STRANDED RNA |
| 摘要 |
This invention relates to compounds, compositions, and methods useful for reducing CKAP5 target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents. |
| 申请公布号 |
US2015315583(A1) |
申请公布日期 |
2015.11.05 |
| 申请号 |
US201314651087 |
申请日期 |
2013.12.13 |
| 申请人 |
DICERNA PHARMACEUTICALS, INC. |
发明人 |
Brown Bob D.;Dudek Henryk T. |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated nucleic acid comprising an oligonucleotide strand of 15-35 nucleotides in length, wherein said oligonucleotide strand is sufficiently complementary to a target CKAP5 mRNA sequence selected from Tables 11-13 along at least 15 nucleotides of said oligonucleotide strand length to reduce CKAP5 target mRNA expression when said nucleic acid is introduced into a mammalian cell. |
| 地址 |
Watertown MA US |
