PHARMACEUTICAL COMPOSITIONS FOR TREATING PAIN ASSOCIATED WITH DYSMENORRHEA

摘要

Pain associated with primary and secondary dysmenorrhea is relieved in a human suffering there from by administering to the human a pain relieving amount of a synergistically acting sub-therapeutic combination of a nontoxic N-methyl-D-aspartate receptor antagonist such as dextromethorphan, magnesium, dextrorphan, ketamine or pharmaceutically acceptable salt thereof, tramadol or its analog such as recemic tramadol or an analogously acting molecular entity or pharmaceutically acceptable salt thereof, and an anticonvulsant and/or a tricyclic anti-depressant or pharmaceutically acceptable salt thereof, and optionally in sustained release dosage form.

主权项

1. A method for the treatment of pain associated with dysmenorrhea by administering a pharmaceutical composition comprising a synergistic combination of:
a) between 30 mg and 45 mg of dextromethorphan (between 36 mg and 54 mg of dextromethorphan hydrochloride monohydrate); b) between 35 mg and 50 mg of tramadol (between 39 mg and 57 mg of tramadol hydrochloride); and c) between 45 mg and 180 mg of gabapentin;wherein said dextromethorphan, said tramadol, and said gabapentin are in an immediate release formulation; wherein the said dextromethorphan potentiates the pain relieving effect of tramadol and the gabapentin; the said tramadol potentiates the pain relieving effect of dextromethorphan and the gabapentin; and the said gabapentin potentiates the pain relieving effect of dextromethorphan and the tramadol.