发明名称 |
INTERMEDIATE METABOLISM PRODUCTS TO POTENTIATE AMINOGLYCOSIDE ANTIBIOTICS IN BACTERIAL INFECTIONS |
摘要 |
Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and treatment with one or more proton motive force (PMF) stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known. |
申请公布号 |
WO2015031765(A3) |
申请公布日期 |
2015.11.05 |
申请号 |
WO2014US53425 |
申请日期 |
2014.08.29 |
申请人 |
TRUSTEES OF BOSTON UNIVERSITY;THE GENERAL HOSPITAL CORPORATION |
发明人 |
COLLINS, JAMES J.;MEYLAN, SYLVAIN;MOSKOWITZ, SAMUEL |
分类号 |
A61K31/7036;A61K31/00;A61P31/00 |
主分类号 |
A61K31/7036 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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