| 发明名称 |
METHODS OF INHIBITING CANCER STEM CELLS WITH HMGA1 INHIBITORS |
| 摘要 |
The presently disclosed subject matter relates to methods of inhibiting cancer stem cells and growth of aggressive and/or poorly differentiated metastatic tumors comprising the cancer stem cells with HMGA1 inhibitors. The presently disclosed subject matter also provides methods of selecting and treating a subject with aggressive and/or poorly differentiated metastatic cancer using HMGA1 inhibitors. |
| 申请公布号 |
US2015315589(A1) |
申请公布日期 |
2015.11.05 |
| 申请号 |
US201514701586 |
申请日期 |
2015.05.01 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
SMITH RESAR LINDA M.;HUSO DAVID;COPE LESLIE |
| 分类号 |
C12N15/113;A61K31/7068;A61K31/713;G01N33/574;C12Q1/68 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inhibiting at least one cancer stem cell, the method comprising contacting the at least one cancer stem cell with an effective amount of at least one HMGA 1 inhibitor. |
| 地址 |
Baltimore MD US |
