发明名称 ANTIMICROBIAL COMPOUNDS
摘要 The present invention relates to certain tetramic acid derivatives and, in particular, bicyclic tetramic acid derivatives that are suitable for use in the preparation and development of antimicrobial (e.g. antibacterial or antifungal) compositions. The present invention also relates to the use of such compounds as antimicrobial (e.g. antibacterial or antifungal agents) and, in particular, as topical antibacterial or antifungal agents.
申请公布号 US2015313233(A1) 申请公布日期 2015.11.05
申请号 US201314410559 申请日期 2013.06.25
申请人 ISIS INNOVATION LIMITED 发明人 MOLONEY Mark;JEONG Yong-chu
分类号 A01N43/90;C07D513/04;C07D498/04 主分类号 A01N43/90
代理机构 代理人
主权项 1. A compound of the formula I or II below: wherein: X is O, S or SO2, Y is OH or C1 to C10 alkyl, R1, R2 and R4 are each independently selected from H and C1 to C6 alkyl, R3 is selected from a functional group selected from H, C1 to C6 alkyl, and a carbonyl-containing group, R12 is H, alkenyl, aryl, trihaloalkyl and C1 to C6 alkyl, R5 and R7 are each a group of the formula L1-L2-R6 or L2-L1-R6, where L1 is a linker of the formula —[CR8R9]12—, where n is an integer of from 0 to 12, and R8 and R9 are each independently selected from H or C1 to C2 alkyl, and where L2 is absent or a linker that is selected from O, S, SO, SO2, N(R′), C(O), C(O)O, OC(O), [O(CR′2)r]s, [(CR′2)rO]sCH(OR′), C(O)N(R′), N(R′)C(O), N(R′)C(O)N(R′), SO2N(R′) or N(R′)SO2 where R′ and R″ are each independently selected from hydrogen and a C1 to C2 alkyl, and where r is 1 or 2 and s is 1 to 4, and where R6 is selected from OR13, heterocyclic and C1 to C25 hydrocarbyl group, wherein R13 is a C1 to C6 alkyl, and said heterocyclic and hydrocarbyl group is optionally substituted with at least one functional group selected from alkenyl, alkyl, aryl, halo, trihaloalkyl, alcohol, keto, S(O)R13, sulfonyl, thio-alcohol, ester, thioester, ether, thioether, amide, thioamide, urea, thiourea, ═O, ═S, amine and heterocyclic group.
地址 Oxford GB