| 摘要 |
Provided is a compound which is useful as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like. The present inventors have investigated compounds having a 5-HT2C receptor agonist activity and have found that the benzazepine compounds of the present invention have an excellent 5-HT2C receptor agonist activity, thereby completing the present invention. That is, the benzazepine compounds of the present invention have a 5-HT2C receptor agonist activity and can be used as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like. |
| 主权项 |
1. A compound of the formula (II) or a salt thereof: (wherein R11a and R11b are respectively the same or different and each represents —H or C1-6 alkyl, or are combined to form oxo, R21a and R21b are respectively the same or different and each represents —H or C1-6 alkyl which may be substituted with —O—C1-6 alkyl, R31 represents —H, C1-6 alkyl which may be substituted, C3-8 cycloalkyl, aryl which may be substituted, —SO2—C1-6 alkyl, or a hetero ring which may be substituted, R41 represents —H, halogen, cyano, C1-6 alkyl which may be substituted, C2-6 alkenyl, aryl which may be substituted, C3-8 cycloalkyl which may be substituted, an aromatic hetero ring, or an oxygen-containing hetero ring, R51 represents —H, halogen, C1-6 alkyl, C3-8 cycloalkyl, aryl, or an aromatic hetero ring, R61 and R71 are the same or different and each represents —H or C1-6 alkyl, X1 represents —C(RA1)(RB1)— or —O—, and RA1 and RB1 are the same or different and each represents —H or C1-6 alkyl, provided that (i) in the case where R11a, R11b, R21a, R21b, R41, R51, and R71 are respectively —H and X1 is —O—, R31 is a group other than —H, —CO-methyl, or —SO2-methyl, and (ii) in the case where R11a and R11b are combined to form oxo, R21a, R21b, R41, R51, R61, and R71 are respectively —H, and X1 is —O—, R31 is a group other than —H or methyl). |
