SYSTEMS AND METHODS FOR ANALYZING BIOLOGICAL PATHWAYS FOR THE PURPOSE OF MODELING DRUG EFFECTS, SIDE EFFECTS, AND INTERACTIONS

摘要

Systems and methods for analyzing biological pathways are described. The techniques describe herein may enable the selection of candidate drugs to be prioritized. The systems and methods described herein provide visualizations for the impact of a drug on a gene signaling pathway. A visualization may be based on gene signaling pathway topology information and a determined gene expression level equivalent value for a drug.

主权项

1. A method of modeling effects of a drug on a gene signaling pathway, the method comprising:
receiving topology information associated with a gene signaling pathway; determining a gene expression level equivalent value for a drug; and calculating the impact of the drug on the gene signaling pathway based on the received topology information and the determined gene expression level equivalent value.