| 发明名称 |
SURFACE-MODIFIED IRON OXIDE PARTICLES FOR CANCER ABLATION |
| 摘要 |
An object of the present invention is to provide surface-modified ferromagnetic iron oxide particles suitable for electromagnetic-induction cancer ablation, which have excellent heat generation properties and also have excellent dispersion stability in a medium for injection. The surface-modified iron oxide particles for cancer ablation of the present invention as a means for achieving the object are characterized in that a block copolymer of polyethylene glycol and polystyrene having a phosphorous acid group in the side chain is bound to the surface of ferromagnetic iron oxide particles having a plate-like shape with a length of 20 to 200 nm and a length-to-thickness ratio of 1.5 to 30 and having magnetic properties such that the coercivity is 30 to 300 Oe, the saturation magnetization is 20 to 80 emu/g, and the squareness ratio of the magnetic hysteresis loop is 0.20 to 0.50. |
| 申请公布号 |
US2015313994(A1) |
申请公布日期 |
2015.11.05 |
| 申请号 |
US201314427142 |
申请日期 |
2013.09.10 |
| 申请人 |
(UNIVERSITY OF TSUKUBA) |
发明人 |
ODA Tatsuya;NAGASAKI Yukio;ASAI Kei;KITA Eiji;YANAGIHARA Hideto;OHKOHCHI Nobuhiro;KISHIMOTO Mikio |
| 分类号 |
A61K41/00;A61K47/48;A61K9/00 |
主分类号 |
A61K41/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Surface-modified iron oxide particles for cancer ablation, characterized in that a block copolymer of polyethylene glycol and polystyrene having a phosphorous acid group in the side chain is bound to the surface of ferromagnetic iron oxide particles having a plate-like shape with a length of 20 to 200 nm and a length-to-thickness ratio of 1.5 to 30 and having magnetic properties such that the coercivity is 30 to 300 Oe, the saturation magnetization is 20 to 80 emu/g, and the squareness ratio of the magnetic hysteresis loop is 0.20 to 0.50. |
| 地址 |
Tsukuba-shi, Ibaraki JP |
