发明名称 |
COMPOSITIONS AND METHODS OF TREATING INFLAMMATORY BOWEL DISEASE |
摘要 |
A method of treating a lymphocyte mediated inflammation in a subject including administering a therapeutically effective amount of a cell delivery composition to the subject, the cell delivery composition of the application including an immunosuppressive cell and a plurality of targeting moieties that bind to endothelial cell adhesion molecules expressed by endothelial cells as a result of a lymphocyte mediated inflammatory response in the subject, the targeting moieties coated on and linked to the immunosuppressive cell and enhancing adherence of the immunosuppressive cell to an endothelial cell at a site of lymphocyte mediated inflammation when administered to the subject systemically, wherein the cell delivery composition, suppresses lymphocyte mediated inflammation in the subject. |
申请公布号 |
US2015313945(A1) |
申请公布日期 |
2015.11.05 |
申请号 |
US201514591621 |
申请日期 |
2015.01.07 |
申请人 |
Case Western Reserve University |
发明人 |
Dennis James E.;Kean Thomas;Ko Inkap |
分类号 |
A61K35/28;C07K16/28;A61K9/00 |
主分类号 |
A61K35/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Cleveland OH US |