Low Affinity FCGR Deficient Mice

摘要

Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided.

主权项

1. A transgenic mouse whose genome comprises a contiguous human nucleotide sequence that encodes at least two α-chains of a human FcγR α-chain gene selected from FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB, and a combination thereof, wherein the contiguous human nucleotide sequence replaces mouse FcγR sequences in a mouse FcγR locus, and wherein the mouse comprises a functional FcR γ-chain gene.