COMPOSITIONS AND METHODS FOR INTRADERMAL VACCINE DELIVERY

摘要

The present invention relates, generally, to compositions comprising at least one antigen encapsulated within at least one fibrous polymer matrix and their use in intradermal vaccine delivery. It has been discovered that the intradermal delivery of antigens into the antigenpresenting cell-rich layers of the skin requires less antigen than traditional vaccine delivery methods and is still capable of eliciting an immune response comparable to that observed with traditional vaccine delivery methods.